abstract：:Approximately one third of the world's population is infected with Mycobacterium tuberculosis,yet each year a small proportion of those individuals progress to an active disease state. Early identification and treatment of such individuals is essential to reduce transmission; however, genetic and immunological correla...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Beamer GL,Turner J

更新日期：2005-11-01 00:00:00

abstract：INTRODUCTION:Patients with severe hemophilia A often develop inhibitors (antibodies) against transfused factor VIII. MATERIAL/METHODS:One hundred thirteen Polish patients with severe hemophilia A, who had been treated on demand with cryoprecipitate until 1992 and exclusively with factor VIII concentrates after 1995, w...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Sawecka J,Skulimowska J,Windyga J,Lopaciuk S,Kościelak J

更新日期：2005-07-01 00:00:00

abstract：:Phagocytes such as neutrophils and monocytes play an essential role in host defenses against microbial pathogens. Reactive oxygen species (ROS), such as superoxide anion, hydrogen peroxide, the hydroxyl radical, and hypochlorous acid, together with microbicidal peptides and proteases, constitute their antimicrobial ar...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： El-Benna J,Dang PM,Gougerot-Pocidalo MA,Elbim C

更新日期：2005-05-01 00:00:00

abstract：:The cytokine IL-15 performs numerous functions, such as promotion of growth and survival, on a plethora of cell types from both the lymphoid and non-lymphoid compartments. Therefore, mice genetically engineered to either lack or overexpress functional IL-15 display reduced immunological responses and leukemia, respect...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Van Belle T,Grooten J

更新日期：2005-03-01 00:00:00

abstract：:After several decades of research into the macrophage migration inhibitory factor (MIF), its diverse actions in the immune system are yet to be fully revealed. What has become clear is that MIF plays an important role in both innate and adaptive immunity. However, while several pathways mediating the function of MIF i...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Denkinger CM,Metz C,Fingerle-Rowson G,Denkinger MD,Forsthuber T

更新日期：2004-11-01 00:00:00

abstract：:Over the last 18 years of study in one of our laboratories, we have observed the development of residual disease and latent reservoirs as major problems in the long-term therapy of HIV-1-infected individuals on highly active antiretroviral therapy (HAART). It was shown in the early 1990 's that HAART, as it is present...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Pomerantz RJ

更新日期：2004-09-01 00:00:00

abstract：:The Ly-6 locus on mouse chromosome 15 encodes a family of 10-12 kDa proteins that are linked to the cell surface by a glycosylphosphatidyl-inositol anchor and have cell signaling and cell adhesion properties. Expression of Ly-6 proteins is tightly regulated during development; these proteins continue to serve as excel...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Bamezai A

更新日期：2004-07-01 00:00:00

abstract：:The migration of B lymphocytes into distinct microenvironments in secondary lymphoid tissues and maintenance of cells in these micro-domains is strictly structured and likely supports the proper regulation of immune responses to both foreign and self-antigens. Chemokines' and other chemoattactants' signals serve as si...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Moratz C,Harrison K,Kehrl JH

更新日期：2004-01-01 00:00:00

abstract：:Mast cells (MCs) are found widely distributed in tissues and contribute to regulation of inflammatory responses and ongoing modulation of the tissues. Although MCs are important in a variety of processes, including innate immunity, their role in allergic disease has received increasing attention in the past decade. MC...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Kulka M,Befus AD

更新日期：2003-01-01 00:00:00

abstract：:Although the mechanisms by which Bcl-2 family proteins control the apoptotic machinery of the cell are not fully understood, it becomes clear that the role of BH3-only proteins consists in serving as sensors or sentinels of cellular damage, transducing the apoptotic stimuli to the mitochondria. For this reason, mammal...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Fleischer A,Rebollo A,Ayllón V

更新日期：2003-01-01 00:00:00

abstract：:Wegener's granulomatosis (WG) is a small-vessel vasculitis associated with various clinical manifestations, among which the most common are respiratory tract disease and glomerulonephritis leading to renal failure. The pathogenesis of vascular injury in WG is ascribed to antineutrophil cytoplasmic antibodies (ANCA) di...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Watorek E,Boratyńska M,Klinger M

更新日期：2003-01-01 00:00:00

abstract：:Regulation of monocyte/macrophage function is important in coordinating immune responses. Their contact with invading pathogens activates signaling pathways that provoke pro-inflammatory gene expression and thus causing a locally restricted inflammation. Recently, the peroxisome proliferator-activated receptor gamma (...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： von Knethen A,Brüne B

更新日期：2003-01-01 00:00:00

abstract：:In the era of the Human Genome Project, quantitation of gene expression by tumor/host cells is of paramount importance to investigate gene patterns responsible for cancer development, progression and response/resistance to treatment. Quantitative real-time PCR (qrt-PCR) technology has recently reached a level of sensi...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Mocellin S,Rossi CR,Marincola FM

更新日期：2003-01-01 00:00:00

abstract：:The chicken is a foundational model for immunology research and continues to be a valuable animal for insights into immune function. In particular, the bursa of Fabricius can provide a useful experimental model of the development of B lymphocytes. Furthermore, an understanding of avian immunity has direct practical ap...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Funk PE,Palmer JL

更新日期：2003-01-01 00:00:00

abstract：:New treatment strategies for HIV/AIDS are very successful in reducing viral load. However, reconstitution of the immune system takes about one year and may be insufficient or remain incomplete. During this time the patient remains prone to opportunistic infections as a result of the complex immune dysfunction caused b...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Von Aulock S,Hartung T

更新日期：2002-01-01 00:00:00

abstract：:Many features of the interferon gamma (IFN-gamma) signaling pathway would suggest that it is anti-tumorigenic. The IFN-gamma signaling pathway leads to apoptosis and to the expression of immune function proteins that could cooperate with T cells in the destruction of tumor. Various lines of experimental approach have,...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Blanck G

更新日期：2002-01-01 00:00:00

abstract：:The dry thermal glycation method was used to conjugate D-glucose and D-fructose with bovine serum albumin. Reactions were conducted at 50-104 degrees C for 30 min. Depending on temperature, different levels of substitution were achieved. In the case of D-glucose, average substitution levels of up to 53 mol glucose/mol...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Kańska U,Boratyński J

更新日期：2002-01-01 00:00:00

abstract：:Clinical trials have shown that the type I interferon (IFN)-alpha/beta have some beneficial effects on organ-specific autoimmune diseases, such as Behcet's diseases and multiple sclerosis, although the precise mechanisms remain largely unresolved. T helper cells 1 (Th1)-mediated autoimmune responses are involved in th...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Mizuguchi J,Takeuchi M,Usui M

更新日期：2002-01-01 00:00:00

abstract：:There is a strong epidemiologic relationship between chronic hepatitis C virus (HCV) infection and the development of hepatocellular carcinoma, although the cellular and molecular mechanisms of tumor formation remain to be firmly established. Clearly, HCV is associated with the development of chronic hepatitis and cir...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Feitelson M

更新日期：2001-01-01 00:00:00

abstract：:Morphological changes and the content of free carboxyl groups in bovine collagen (type I) film under the influence of trypsin, hydrochloric acid (HCl) and ethylenediaminetetraacetic acid (EDTA) were studied. Incubation with trypsin and HCl was found to cause some delamination of the film and the appearance of some low...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Lesiak-Cyganowska E,Sladowski D,Komender J

更新日期：2001-01-01 00:00:00

abstract：:Signal transducer and activator of transcription (STAT) is a family of transcription factors composed of seven members. Gene-targeted mice of each STAT family protein displayed defective responses to cytokines, demonstrating an important role in cytokine-mediated biological responses. However, unlike the mice lacking ...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Takeda K,Akira S

更新日期：2001-01-01 00:00:00

abstract：:The activity of natural killer (NK) cells is regulated by surface receptors that recognize class I MHC. Murine NK cells express a large family of lectin-related receptors (Ly49s) to perform this function, while human NK cells utilize a separate group of proteins containing Ig-related domains (KIRs). Although these rec...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Makrigiannis AP,Anderson SK

更新日期：2001-01-01 00:00:00

abstract：:This study was to evaluate the levels of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) and the cytokine inhibitors soluble TNF-alpha receptor (sTNFR) and interleukin (IL-1) receptor antagonist (IL-1ra), as well as the intensity of oxidative metabolism of peripheral blood polymorphonuclear leukoc...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Sikora JP,Chlebna-Sokół D,Dabrowska I,Lipczyński D,Chrul S

更新日期：2001-01-01 00:00:00

abstract：:Different infections are the most common complication of immunosuppressive therapy. In this context, the effect of cyclosporine A (CsA) on the innate antiviral immunity of mice was studied. The presence of immunity was shown by infection of resident peritoneal cells (RPC) of BALB/c mice with herpes simplex virus type ...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Zaczyńska E,Olszewska ZB

更新日期：2001-01-01 00:00:00

abstract：:We compared HLA antigen expression on new B-lymphoblastoid cell line (B-LCL) HAJ with that on B-LCLs expressing normal HLA levels as well as on B-LCLs derived from bare lymphocyte syndrome (BLS) patients and in vitro mutated B-LCLs of BLS-like phenotype. HAJ cells had no expression of HLA class II and low expression o...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Nowak I,Pochroń B,Kozlowska A,Dubis J,Kuśnierczyk P

更新日期：2001-01-01 00:00:00

abstract：:Cytokines are small proteins or glycoproteins that transmit information from one cell to another. Most cells in the body secrete and respond to cytokines and their effects have been described on a myriad of cellular functions. Cytokine interactions may not be linear, thus making the system extremely intricate and with...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Vecchiarelli A

更新日期：2000-01-01 00:00:00

abstract：:1307 patients with suppurative bacterial infections caused by multidrug-resistant bacteria of different species were treated with specific bacteriophages (BP). BP therapy was highly effective; full recovery was noted in 1123 cases (85.9%). In 134 cases (10.9%) transient improvement was observed and only in 50 cases (3...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Weber-Dabrowska B,Mulczyk M,Górski A

更新日期：2000-01-01 00:00:00

abstract：:Two major classes of lipids participating in signaling cascades in immune cells are known today. One comprises glycerol-based lipids with diacylglycerol as its most prominent member that mediates the activation of classical and novel protein kinase C molecules. The second group contains the sphingolipids, with the bes...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Prieschl EE,Baumruker T

更新日期：2000-01-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection produces a profound impairment of immune functions that antiretroviral therapy is unable to restore. Because of its immuno-enhancing properties, interleukin 2 (IL-2) has been used as a therapeutic tool in HIV+ subjects. IL-2 produces an increase of CD4 and CD8 lymphocyte ab...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： De Paoli P

更新日期：2000-01-01 00:00:00

abstract：:Recent studies have shown marked geographic variation associated with Epstein-Barr virus (EBV) in pediatric Burkitt's lymphomas and Hodgkin's disease. In the present study we investigated 30 cases of pediatric extranodal high grade non-Hodgkin's lymphomas (NHL) from Turkey with an abdominal localisation. To classify t...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Tinguely M,Bründler MA,Gogos S,Kerl K,Borisch B

更新日期：2000-01-01 00:00:00

abstract：:Until recently, the traditional view was that tolerance to self antigens was maintained by a combination of physical deletion, in the thymus, and functional deletion, in the periphery, of autoreactive T cells. There is now, however, abundant evidence that the normal T cell repertoire contains overtly autoreactive T ce...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Seddon B

更新日期：2000-01-01 00:00:00

abstract：:In rheumatoid arthritis (RA), T cells infiltrate into the synovial membrane where they initiate and maintain activation of macrophages and synovial fibroblasts, transforming them into tissue-destructive effector cells. The diversity of the disease process and the formation of complex lymphoid microstructures indicate ...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Weyand CM,Bryl E,Goronzy JJ

更新日期：2000-01-01 00:00:00

abstract：:There is an increasing evidence that CD3+ cells, bearing gammadelta T cell receptors representing a minor subpopulation of T cells in the peripheral blood of humans are involved in the development of autoimmunity. The aim of the present study was determination of the gammadelta T cell subpopulation levels in the perip...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Kretowski A,Myśliwiec J,Kinalska I

更新日期：2000-01-01 00:00:00

abstract：:Determinations of the blood serum levels of interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and their soluble receptors (sIL-6R, sTNFR) in denture stomatitis patients (DS) were performed. Serum levels of interleukins and their soluble receptors were measured using the ELISA method. In all examined patien...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Pietruski JK,Pietruska MD,Jabłońska E,Sacha P,Zaremba M,Stokowska W

更新日期：2000-01-01 00:00:00

abstract：:High-dose chemotherapy in conjunction with bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT) is increasingly being used for treatment of patients with hematological malignancies. Residual tumor cells, resistant to high-dose chemoradiotherapy, are responsible for reccurence of the ...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Frydecka I,Kosmaczewska A,Boćko D,Ciszak L,Kaczmarek P

更新日期：1999-01-01 00:00:00

abstract：:Genomic catastrophism is the belief that unique genetic events, unlike those observed in recent evolutionary history, played a key role in the origin of vertebrate adaptations. Catastrophist hypotheses have been particularly popular is accounting for the origin of vertebrate specific immunity. Two major such hypothese...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Hughes AL

更新日期：1999-01-01 00:00:00

abstract：:The major histocompatibility complex (MHC) encodes highly polymorphic cell surface glycoproteins that form the basis of immunological individuality. It has been postulated that MHC besides its role in immune defence also determines behavior through formation of specific odor cues. In addition several studies have impl...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Janssen E,Zavazava N

更新日期：1999-01-01 00:00:00

abstract：:The aim of this study was to analyze association between HLA class I antigens and sarcoidosis in Poland. HLA-A, B, C antigens in a group of 100 patients suffering from sarcoidosis and in a group of 100 healthy blood donors were determined. Histocompatibility typing was performed by the NIH method using commercially av...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Dubaniewicz A,Szczerkowska Z

更新日期：1999-01-01 00:00:00

abstract：:The bases for an efficient anti-tumor immune response begin to be better defined. Nonetheless, neoplastic cells develop various strategies to escape immune surveillance, which are discussed here in order to better design the therapeutic possibilities of immune manipulation. The absence of specific tumor antigen as wel...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Costello RT,Gastaut JA,Olive D

更新日期：1999-01-01 00:00:00

abstract：:Recent data have demonstrated that presence of apolipoprotein E (APOE) epsilon *4 allele is a major risk factor of Alzheimer's disease (AD). We determined the APOE genotypes in 64 patients with sporadic probable AD and 43 non-demented aged controls selected from Poznań region and the western part of Poland using the p...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Kowalska A,Florczak J,Pruchnik-Wolińska D,Kraszewski A,Wender M

更新日期：1998-01-01 00:00:00